Table 5.
Cox's proportional hazard analysis for the combined end-point of overall mortality and need for aortic valve replacement in the subgroup of 188 patients without a straightaway indication for AVR.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Model 1 | ||||||
| AVC index (/100 AU/m2) | 1.10 | 1.08–1.13 | <0.001 | 1.10 | 1.08–1.13 | <0.001 |
| AVC (/100 AU) | 1.05 | 1.04–1.07 | <0.001 | |||
| AVC density (/100 AU/cm2) | 1.15 | 1.10–1.21 | <0.001 | |||
| Mean gradient (/mmHg) | 1.04 | 1.02–1.05 | <0.001 | |||
| Peak velocity (/m/s) | 2.13 | 1.65–2.74 | <0.001 | |||
| Effective orifice area (/cm2) | 0.16 | 0.00–0.37 | <0.001 | |||
| Age (/year) | 1.03 | 1.01–1.05 | 0.009 | |||
| LA dimension (/10 mm) | 1.07 | 1.02–1.14 | 0.012 | |||
| TR <2/4 | 0.25 | 0.00–0.87 | 0.029 | |||
| Model 2 | ||||||
| High AVC | 3.51 | 2.36–5.24 | <0.001 | 2.82 | 1.85–4.31 | <0.001 |
| High AVC density | 3.31 | 2.20–4.99 | <0.001 | |||
| High AVC index | 3.13 | 2.10–4.66 | <0.001 | |||
| Mean gradient (/mmHg) | 1.04 | 1.02–1.05 | <0.001 | |||
| Peak velocity (/m/s) | 2.13 | 1.65–2.74 | <0.001 | |||
| Effective orifice area (/cm2) | 0.16 | 0.00–0.37 | <0.001 | 0.31 | 0.00–0.69 | 0.004 |
| Age (/year) | 1.03 | 1.01–1.05 | 0.009 | 1.03 | 1.01–1.05 | 0.024 |
| LA dimension (/10 mm) | 1.07 | 1.02–1.14 | 0.012 | |||
| TR < 2/4 | 0.25 | 0.00–0.87 | 0.029 | |||
LA, left atrium; TR, Tricuspid regurgitation severity.