Table 2.
Hazard ratios associated with characteristics identified during presurgical planning.
Presurgical characteristic—univariate analysis | HR | p | 95% Confidence interval | #with/without characteristic | #postop sz with/without characteristic |
Months to 1st sz with/without characteristic |
---|---|---|---|---|---|---|
No unilateral MTS | 2.22 | 0.108 | 0.84–5.87 | 14/16 | 10/7 | 4.8/10.7 |
No unilateral PET hypometabolism | 2.34 | 0.115 | 0.81–6.72 | 9/18 | 7/7 | 7.9/7.0 |
Non-temporal lobe interictal findings | 2.80 | 0.056 | 0.97–8.03 | 16/14 | 12/5 | 7.1/7.6 |
Ipsilateral temporal lRSA | 4.05 | 0.005 | 1.51–10.86 | 8/22 | 8/9 | 7.5/7.0 |
Non- or contra-lateralizing seizure onset |
4.31 | 0.006 | 1.51–12.34 | 6/24 | 6/11 | 4.5/8.7 |
Non- or contra-lateralizing seizure onset or Ipsilateral temporal lRSA |
7.13 | <0.001 | 2.41–21.07 | 12/18 | 12/5 | 6.9/8.0 |
Results of a univariate analysis, with each listed parameter tested as an independent variable. MTS, mesial temporal sclerosis on MRI. IRSA, interictal regional slow activity. HR, hazard ratio for recurrent seizures after surgery, calculated with the Cox proportional hazards model.
with/without characteristic: the number of subjects in the cohort who had the defining characteristic/the number of subjects in the cohort who did not have the defining characteristic; there were 30 subjects in the cohort.
postop sz with/without characteristic: the number of subjects in the group with the characteristic that had a postoperative seizure/the number of subjects in the cohort who did not have the defining characteristic that had a postoperative seizure. Months to 1st sz: the average number of months between surgery and the first seizure in subjects who had a seizure.