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. 2021 May 17;12:683710. doi: 10.3389/fimmu.2021.683710

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Copyright © 2021 Schell and Rahman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNAs that Impact B Cell Development in the Bone Marrow. Many miRNAs have been identified in the regulation of B cell development through each of the individual stages. This indicates a dynamic regulation of miRNA expression is required for proper developmental programs. miRNA regulation involved at these different stages is depicted. miRNAs that positively regulate these specific steps are depicted in blue. miRNAs that negatively regulate these specific steps are depicted in red. miRNAs are indicated at their confirmed or predicted stages of activity. HPSC, hematopoietic progenitor stem cell; MPP, multipotent progenitor; CLP, common lymphocyte progenitor.