Figure 3.

Proposed model of how the lack of glucocorticoid receptor (GR) in macrophages could be detrimental to gastrointestinal tissue homeostasis. In the dextran sodium sulfate (DSS)-induced colitis model, deletion of GR in myeloid cells delays the resolution of inflammation through an increase in the number of pro-inflammatory macrophages which perpetuates tissue damage. Other immune cells, such as B cells, dendritic cells and ILCs relevant to the intestinal physiology have been deliberately neglected to highlight the function of macrophages.