Table 2.

Results of the gene-based likelihood ratio tests (p-values for each test are shown)

Disease/gene	HLA-A	HLA-B	HLA-C	HLA-DPB1	HLA-DQA1	HLA-DQB1	HLA-DRB1
Any infection	0.1759	0.6097	0.7975	0.6141	0.1708	0.5422	0.4631
Bacterial infection	0.3187	0.1235	0.05251	0.7455	0.7642	0.9248	0.8715
CNS infection	NA	NA	0.5737	0.01279a	0.6255	0.477	NA
Gastrointestinal infection	0.5783	0.5979	0.9051	0.03784	0.09455	0.2796	0.4751
Genital infection	1	1	0.3614	0.1255	0.4617	0.2426	NA
Hepatitis infection	NA	NA	NA	NA	0.07716	0.6711	NA
Other infections	0.643	0.6957	0.9214	0.7476	0.01073a	0.08866	0.4972
Otitis infection	0.02872	0.8145	0.6157	0.8382	0.8545	0.8985	0.5372
Pregnancy-related infection	0.6392	NA	0.7479	0.4424	0.8963	0.8691	NA
Respiratory infection	0.437	0.7647	0.2972	0.4032	0.1343	0.09267	0.1911
Sepsis	NA	NA	0.4429	0.7941	0.3766	0.003534a	NA
Skin infection	0.5236	0.02606	0.2706	0.7474	0.5656	0.6319	0.816
Urological infection	0.6288	0.7088	0.02561	0.3027	0.9862	0.6622	0.6907
Viral infection	0.2659	0.2998	0.3384	0.3027	0.03678	0.01402a	0.0467

NA denotes cases in which the regression/likelihood ratio test failed due to small sample sizes, multicollinearity of the alleles, and/or rare alleles

^aThese associations obtained the lowest q-value (27%)