FIGURE 4.

Kaplan-Meier plot representing morbidity from DEARE up to 120 days post 13 Gy partial body irradiation with one hind limb shielded (leg-out PBI). The triple combination (TC, consisting of PEG-hG-CSF, PEG mGM-CSF and PEG hIL-11), vehicle or PEG-hG-CSF (BBT-015) were given subcutaneously 24 h post leg-out PBI (designated by PEG-HGF) and the ACE inhibitor, lisinopril, was started in the drinking water 7 days post irradiation (24 mg m⁻² d⁻¹). All irradiated rats were given supportive care with subcutaneous hydration (40 ml kg⁻¹ d⁻¹) and enrofloxacin (10 mg kg⁻¹ d⁻¹) from days 3–7 to 2–14, respectively,. There was trend in lower morbidity in irradiated rats that received TC + lisinopril compared to irradiated rats that received PEG-hG-CSF, but this was not significant (p = 0.07). Shaded (gray) areas represent the timing for the lung and renal injuries.