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. 2021 May 17;15:612940. doi: 10.3389/fnins.2021.612940

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Copyright © 2021 Tsai, Chen, Lai, Chang, Taira, Chang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The ExAblate Neuro platform simulated the ultrasound beams (light green lines) penetrating through a skull (transparent green around the head) and extracted the maximum [max (I_k)] and minimum [min(I_k)] of the skull intensities along each of the ultrasound. The blue line at the right panel of the (A) delineated the CT image intensity changes along one of the ultrasound beam I_k. A high intensity difference between and cortical and trabecular bone might leaded to a low SS = 0.25 [(B), left] compared to high SS = 0.70, which had a relatively similar intensity between the cortical and trabecular bone [(B), right]. SS, skull score.