Table 1.
Characteristics of pregnant women with syphilis and reporting allergy to penicillin.
| Characteristic | Total Population | High-risk Clinical History | Low-risk Clinical History | Statistical Difference |
|---|---|---|---|---|
| Mean age (year, range) | 25.1 (14–42) | 25.2 (15–41) | 25 (14–42) | NS |
| Mean gestational age (weeks, range) | 19.8 (5–38) | 18.4 (6–33) | 21.6 (5–38) | NS |
| ≥2 criteria for high-risk clinical-history | 56% | 100% | 0% | Definition criteria |
| First criterion high-risk clinical-history | 67% | 74.5% | 17.5% | p < 0.01 |
| Second criterion high-risk clinical-history | 49.5% | 100% | 25% | p < 0.01 |
| Third criterion high-risk clinical-history | 47.3% | 70.6% | 17.5% | p < 0.01 |
| Positive Intradermal Test | 7.7% | 13.72% | 0% | p = 0.02 |
| Anaphylaxis as the initial IHR | 46.2% | 56.9% | 17.5% | p < 0.01 |
IHR: Immediate hypersensitivity reaction.
NS: not significant.
First criterion: IHR to penicillin in the last 10 years.
Second criterion: Clinical manifestation compatible with IHR.
Third criterion: No history of tolerated re-exposure to penicillins after the initial IHR.