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. 2021 May 17;12:575830. doi: 10.3389/fgene.2021.575830

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Copyright © 2021 Zhou, Zheng, Han, Wang, Zhang, Shu, Zhang, Liu and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The CMA approach identifies CNVs upon subjects with a solitary functioning kidney. Several publicly available databases were used as reference resources (see the section “Materials and Methods”). CMA test upon 99 subjects identified a total of 45 CNVs out of 34 subjects. CNVs from 12 fetuses, which accounts for 11.1% of the cohort, were interpreted as pathogenic CNVs. Besides, CMA results included two cases of aneuploidy (one case of triple X cases and one case of Down syndrome). N indicates the number of the fetuses. n indicates the number of the CNVs.