Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;30(11):578–586. doi: 10.1089/scd.2021.0013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Jason A. Halliwell et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 4. — Model for microhomology-mediated tandem amplification in human PSCs. (A) Replication fork stalling is promoted by Alu sequences that form hairpin loops. (B) Repair by microhomology-mediated break-induced replication is initiated by strand invasion at a site of microhomology in the pericentromeric microsatellite on the sister chromatid. (C) Replication proceeds, duplicating 20q11.21. (D) An additional round of strand invasion and resynthesis occurs in examples of (E) tandem triplication. PSC, pluripotent stem cell. Color images are available online.