Figure 4.

Effects of the sulfide oxidation pathway on glucose metabolism.A–C, the rate of glucose consumption (A), lactate production (B), and the lactate:glucose ratio (C) in HT29^scr control SQOR or ETHE1 knockdown cells, incubated as 5% (^w/_v) suspensions in DPBS in the absence or presence of the indicated concentration of Na₂S. The reactions catalyzed by SQOR and ETHE1 are shown above A. The error bars represent the SD on the mean of 3 to 9 independent experiments. ∗Indicates statistically significant difference from controls (lacking Na₂S) (p < 0.05).