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. 2021 Apr 30;296:100736. doi: 10.1016/j.jbc.2021.100736

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Sulfide perturbs adenylate pools.A, time-dependent changes in ATP (circles), ADP (triangles), and AMP (squares) in a 5% suspension of HT29^scr cells in DPBS incubated with (red) or without Na₂S (100 μM, black). Data are representative of three independent experiments. B–E, concentrations of ATP, ADP, and AMP in control (gray bars) and 100 μM Na₂S (blue bars)-treated HT29^scr (B), HCT116 (C), 143B^wt (D), and 143B^Cytb (E) cells. Error bars represent the SD on the mean of three independent experiments, each performed in triplicate. ∗ and ^# Indicate statistically significant differences from control obtained using the paired t test, with p < 0.001 and p < 0.05, respectively. F, sulfide induced a decrease in the total adenine nucleotide pool (ATP + ADP + AMP) in the cell lines shown in B–E. The red line shows the control value in each cell line that is set at 100%. ∗Indicates statistically significant difference from control, p < 0.02.