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. 2021 May 18;64(10):6706–6719. doi: 10.1021/acs.jmedchem.0c02177

Table 2. In Vitro Off-Target Profile of Lead Compound Z-Pst–l-Glu–Hph–NH2.

May1 C. neoformans HIV-1 Pr wild-type Pepsin porcine Renin human Cathepsin D human Cathepsin E human
Ki 12 ± 1 nM 32 ± 5 pM56 1.6 ± 0.3 μM 19 ± 2 μM 620 ± 50 nM 440 ± 70 nM