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. 2021 May 28;15(1):148. doi: 10.3892/mco.2021.2310

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Copyright: © Kitazawa et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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KRAS mutations contributed to anti-EGFR antibody drug resistance in CACO-2 cells. (A) The RPR with cetuximab administration was significantly elevated in all KRAS G12D, G12V, G13D, G12A, G12C, G12S, Q61H and A146T mutants. (B) Similar results were obtained following the administration of panitumumab. ^**P<0.01 vs. drug-free control. KRAS, Kirsten rat sarcoma 2 viral oncogene homolog; RPR, relative proliferation ratio.