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. 2021 May 28;15(1):148. doi: 10.3892/mco.2021.2310

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Copyright: © Kitazawa et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mix culture assay results demonstrated a selective AMG510 inhibitory effect when targeting KRAS G12C in colon cancer cells. (A) The RPR of G12C transgenic cells decreased in an AMG510 concentration-dependent manner. (B) Following AMG510 administration, the RPR of the G12C was greatly reduced. There was a significant difference in G13D; however, there was a slight decrease in RPR. No changes in RPR were observed in KRAS wild type or other KRAS mutations. ^*P<0.05 and ^**P<0.01 vs. drug-free control. KRAS, Kirsten rat sarcoma 2 viral oncogene homolog; RPR, relative proliferation ratio; n.s., not significant.