Figure 19.

Relationship between IVIM measures and age in healthy volunteers. As the age increases, men’s D_slow shows a weak trend of decreasing, while women’s D_slow has significant reduction. Men and women’s PF and D_fast show a trend of increasing. Compared with young women, young men tend to have lower DDVD and D_slow measures and higher PF and D_fast measures; while around the age group of 40-55 years, all these measures are similar between men and women. The IVIM post-processing was based on segmented fittings with threshold b = 60 s/mm² (full fitting shows similar trends). Blue square: males, red ball: females. [Modified with permission from reference [69]].