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. 2021 May 17;12:688508. doi: 10.3389/fphar.2021.688508

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Copyright © 2021 Ishiuchi, Morinaga, Yoshino, Mitamura, Hirasawa, Maki, Tashita, Kondo, Ogawa, Lian, Ogawa-Ochiai, Minamizawa, Namiki, Mimura, Watanabe and Makino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacokinetic profiles of glycyrrhizin (GL) metabolites in female (A–C) and male (D–F) Eisai hyperbilirubinuria rats (EHBRs). Glycyrrhetinic acid (GA, 200 mg/kg) was administered orally to anesthetized EHBRs, and plasma and urine were collected for 12 h. Data of GA, 3MGA, 1, 2, and 3 in (A) and GA, 3MGA, 2, and 3 for (D) are relatively small; their magnified graphs are shown in (B,E), respectively. Concentrations of GA metabolites were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and data are means ± standard error (S.E: n = 4).