Table 2.

Differentially expressed genes in hypothalamus over time across species

Gene ID	Description	LFC	FDR
Aqp3	Aquaporin-3a	−0.6826921	0.0089713
Hsp90ab1a	Heat shock protein HSP 90 beta	−0.5144606	0.00903347
NA	Guanylate binding protein 6	−1.3369143	0.01596747
Serpine1	Plasminogen activator inhibitor 1a	−0.5338288	0.01596747
Ttr	Transthyretin	−0.080078	0.01792675
Prph	Peripherin	0.29781725	0.04287813
Frmpd1	FERM and PDZ domain containing protein 4	0.81441894	0.04287813
Slc6a18	Sodium-dependent neutral amino acid transporter B(0)AT3a	7.32918535	0.04287813
Wrap53	Telomerase Cajal body protein 1a	−0.2558135	0.04287813
Slc25a4a	ADP/ATP translocase 1	−8.0122925	0.04287813
Per1a	Period circadian protein homolog 1	−0.1178588	0.04287813
Cables1	CDK5 and ABL1 enzyme substrate 2	1.11126916	0.04423695
Pxna	Paxillin	0.5140673	0.04423695
Hif1aa	Hypoxia inducible factor 1 alpha	0.97379217	0.0588332
Erich2	Glutamate rich protein 2	2.92340668	0.06351925
Dnah8	Dynein heavy chain 8, axonemala	0.02817643	0.06693531
Ccdc189	Coiled coil domain containing protein 189	−0.3298147	0.07033001
Foxo1	Forkhead box protein O1a	0.17775249	0.07965468
Elmo2	Engulfment and cell motility protein 2a	0.2559439	0.08211435
St6galnac2	Alpha N acetylgalactosaminide alpha-2,6-sialyltransferase 2	1.87200042	0.09137815
Ovol1	Putative transcription factor Ovo like 1	−2.0478213	0.09137815
Ccdc13a	Coiled coil domain containing protein 13	0.52641328	0.09137815
Micalcla	MICAL C-terminal-like protein	1.23718647	0.09701189
Rasgrf2	Ras-specific guanine nucleotide-releasing factor 2a	0.74713328	0.09959283
Riox2	Ribosomal oxygenase 2a	0.48958706	0.09959283

FDR False Discovery Rate, LFC log₂ fold change, NA no annotation. Genes with positive LFC have greater total expression in prairie voles, those with negative LFC have greater total expression in meadow voles. Unannotated genes excluded. See Supplementary Table 4 for full model results. ^aAnnotation obtained from UniprotKB (uniprot.org)