Table 4.
pfhrp2 Amino Acid Repeat types, translated sequences and frequencies (n = 62)
| PfHRP2 | Total (N = 62) | Region | RDT and LM | p-value | |||
|---|---|---|---|---|---|---|---|
| East | West | RDT−/LM + | RDT+/LM + | ||||
| Code | Repeat sequences | (N = 40) | (N = 22) | (N = 24) | (N = 38) | ||
| 1 | AHHAHHVAD | 2.7 ± 1.4 | 1–7 | 0–6 | 2.9 ± 1.5 | 2.6 ± 1.3 | 0.504 |
| 2 | AHHAHHAAD | 11.8 ± 2.2 | 10–17 | 8–13 | 12.1 ± 1.9 | 11.7 ± 2.4 | 0.427 |
| 3 | AHHAHHAAY | 1.2 ± 0.7 | 0–2 | 0–3 | 1.1 ± 0.7 | 1.3 ± 0.7 | 0.457 |
| 4 | AHH | 0.5 ± 0.8 | 0–3 | 0–1 | 0.3 ± 0.6 | 0.6 ± 0.9 | 0.146 |
| 5 | AHHAHHASD | 0.7 ± 0.5 | 0–2 | 0–1 | 0.8 ± 0.5 | 0.6 ± 0.5 | 0.221 |
| 6 | AHHATD | 3.0 ± 1.4 | 1–6 | 2–5 | 3.0 ± 1.3 | 3.0 ± 1.4 | 1 |
| 7 | AHHAAD | 6.5 ± 2.4 | 4–11 | 4–8 | 6.2 ± 2.1 | 6.8 ± 2.5 | 0.317 |
| 8 | AHHAAY | 1.1 ± 0.6 | 0–2 | 1–2 | 1.2 ± 0.8 | 1.1 ± 0.5 | 0.85 |
| 9 | AAY | 0.0 ± 0.0 | 0.0 | 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | NA |
| 10 | AHHAAAHHATD | 1.6 ± 0.7 | 0–3 | 0–2 | 1.9 ± 0.7 | 1.5 ± 0.6 | 0.018 |
| 11 | AHN | 0.0 ± 0.0 | 0.0 | 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | NA |
| 12 | AHHAAAHHEAATH | 0.0 ± 0.0 | 0 | 0 | 0.0 ± 0.0 | 0.0 ± 0.0 | NA |
| 13 | AHHASD | 0.0 ± 0.0 | 0 | 0 | 0.0 ± 0.0 | 0.0 ± 0.0 | NA |
| 14 | AHHAHHATD | 0.3 ± 0.4 | 0–1 | 0–1 | 0.4 ± 0.5 | 0.2 ± 0.4 | 0.097 |
| *New | 0.0 ± 0.3 | 0–2 | 0 | 0.0 ± 0.0 | 0.1 ± 0.3 | 0.324 | |
*New = are sequences observed in Ugandan isolates that had not been reported before. East and West are the Eastern and Western regions of Uganda. Data was given by mean + -SD. P-value was calculated by Student’s t-test or Wilcoxon’s Rank Sum test as appropriate. LM = microscopy