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. 2021 May 31;21:1025. doi: 10.1186/s12889-021-11052-9

Table 1.

Results of hierarchical linear regression analyses of cotinine measures regressed onto smoking factors

Cotinine outcome measure Maximum value Minimum value Range of values Total AUC
B (SE) B (SE) B (SE) B (SE)
Characteristics, Adjusted R2 0.2 0.3 0.1 0.3
Age smoking fairly regularly (years) 1.8 (6.4) −2.0 (3.7) 3.8 (3.3) 1.5 (26.0)
 Duration of non-daily smoking (months) 1.2 (5.4) 0.9 (3.2) 0.3 (2.8) 3.8 (22.0)
 Converted vs. native non-daily smoker −29.3 (72.5) −19.2 (42.6) −10.2 (37.7) − 46.1 (297.0)
 Menthol vs. regular preference 142.7 (62.8)b 118.3 (36.9)a 24.4 (32.6) 727.9 (257.2)b
 NMR (log)d 132.8 (88.2) 60.6 (51.8) 72.1 (45.8) 471.2 (361.2)
 Time to first cigarette after waking (minutes) −0.4 (0.1)a −0.3 (0.1)a − 0.2 (0.1)b −1.9 (0.5)a
 Nicotine dependence severityc −0.6 (17.0) − 0.9 (10.0) 0.3 (8.8) −5.4 (69.7)
Activities, Adjusted R2 0.3 0.2 0.3 0.3
 Performative 14.2 (10.0) 6.0 (6.5) 8.2 (4.7) 49.5 (42.7)
 Leisure 9.9 (6.7) 4.2 (4.4) 5.7 (3.2) 44.7 (28.5)
 Social 2.2 (8.5) −5.5 (5.6) 7.6 (4.0) −15.5 (36.2)
 Interactive 72.0 (19.3)a 40.2 (12.7)a 31.8 (9.1)a 310.6 (82.6)a
Emotions, Adjusted R2 0.3 0.2 0.4 0.2
 Positive 13.7 (7.4) −0.34 (4.9) 14.0 (3.2)a 34.1 (32.6)
 Negative 33.1 (8.7)a 17.6 (5.7)a 15.5 (3.8)a 126.5 (38.3)a
 Mixed 53.5 (29.4) 38.1 (19.4) 15.4 (12.9) 256.0 (130.2)
 Neutral −3.4 (12.2) 1.1 (8.0) −4.4 (5.4) 14.8 (54.0)

Covariates included years of age, sex, race, total family annual income, and marital status

AUC area under the curve, NMR nicotine metabolite ratio

ap < .003, b p < .05

cHooked on Nicotine Checklist total score

dResults did not vary when continuous NMR was replaced by slow vs. normal metabolizer NMR variable