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. 2021 May 30;19:229. doi: 10.1186/s12967-021-02872-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Down-regulated UCA1 or up-regulated miR-122-5p decreases SOX2 expression and the invasion and migration of CD133⁺CaSki cells. a RT-qPCR verified UCA1, miR-122-5p and SOX2 mRNA expression. b Western blot assay detected SOX2, OCT4 and Nanog protein expression. c Effect of UCA1 and miR-122-5p on would healing distance of CD133⁺CaSki cells. d Effect of UCA1 and miR-122–5 on invasion and migration of CD133⁺CaSki cells. N = 3, * P < 0.05 vs. the Exo + siRNA-NC group, # P < 0.05 vs. the Exo + mimic-NC group. & P < 0.05 vs. the Exo + pcDNA-UCA1 + mimic-NC group. Measurement data were depicted as mean ± standard deviation, comparisons among multiple groups were assessed by one-way analysis of variance followed with LSD-t