Table 4.
Comparison of hemostasis parameters between study participants with and without increased liver fat content.
| Controls (N = 66) | Fatty liver (N = 60) | p-value | p-valuea | p-valueb | p-valuec | p-valued | |
|---|---|---|---|---|---|---|---|
| PT (%) | 88 (79–97) | 90 (80–98) | ns | ns | ns | ns | ns |
| aPTT (sec) | 27 (25–29) | 27 (25–29) | ns | ns | ns | ns | ns |
| Fibrinogen (mg/dl) | 264 (228–298) | 298 (253–339) | 0.0182 | ns | ns | ns | ns |
| D-Dimer (μg/ml FEU) | 0.5 (0.4–0.8) | 0.6 (0.3–0.9) | ns | ns | ns | ns | ns |
| Factor II (%) | 97 (89–106) | 100 (94–108) | ns | ns | ns | ns | ns |
| Factor VII (%) | 90 (72–105) | 99 (88–121) | 0.0049 | 0.0169 | ns | ns | ns |
| Factor VIII (%) | 90 (75–116) | 114 (93–131) | 0.0098 | ns | ns | ns | ns |
| Factor IX (%) | 103 (89–117) | 104 (91–119) | ns | ns | ns | ns | ns |
| Antithrombin (%) | 102 (97–109) | 97 (92–103) | 0.0025 | ns | ns | ns | ns |
| Protein C (%) | 111 (101–123) | 124 (113–138) | 0.0006 | 0.0009 | 0.0177 | 0.0209 | 0.0240 |
| Protein S (%) | 89 (78–108) | 109 (98–120) | <0.0001 | 0.0001 | 0.0035 | 0.0036 | 0.0078 |
Results are presented as median and interquartile range (1st – 3rd).
The variation inflation index (VIF) was <3.5 for all analyses.
Abbreviations: PT: prothrombin time; aPTT: activated partial thromboplastin time; ns: not significant; SCAT: subcutaneous abdominal adipose tissue; VAT: visceral adipose tissue.
a
p-value adjusted for age, sex, and BMI.
b
p-value adjusted for age, sex, BMI, and insulin sensitivity.
c
p-value adjusted for age, sex, BMI, insulin sensitivity, SCAT, and VAT.
d
p-value adjusted for age, sex, BMI, insulin sensitivity, SCAT, VAT, and genotype (PNPLA3I148MM/MI and TM6SF2E167KK/KE).