Table 2.
Integrated discrimination improvement (IDI), category-free net reclassification improvement (cfNCI), and AUC difference with the addition of CCL14 to a reference clinical model with baseline serum creatinine and non-renal APACHE III score
| Value | 95% CI | P value | |
|---|---|---|---|
| IDI | 0.065 | 0.005–0.172 | < 0.001 |
| IDI: event | 0.048 | 0.003–0.141 | < 0.001 |
| IDI: non-event | 0.017 | 0.002–0.035 | < 0.001 |
| cfNRI | 0.864 | 0.389–1.276 | < 0.001 |
| cfNRI: event | 0.322 | 0.051–0.633 | 0.004 |
| cfNRI: non-event | 0.542 | 0.272–0.713 | < 0.001 |
| AUC ref model | 0.768 | 0.662–0.872 | < 0.001 |
| AUC new model | 0.834 | 0.738–0.918 | < 0.001 |
| AUC difference | 0.065 | 0.007–0.143 | < 0.001 |
| Model | Variable | OR | 95% CI | P value |
|---|---|---|---|---|
| Reference | Non-renal APACHE | 1.85 | 1.25–2.73 | 0.002 |
| Baseline serum creatinine | 2.26 | 1.42–3.62 | 0.001 | |
| New | Non-renal APACHE | 1.63 | 1.12–2.39 | 0.012 |
| Baseline serum creatinine | 2.09 | 1.24–3.50 | 0.005 | |
| CCL14 | 1.63 | 1.21–2.19 | 0.001 |
Event is persistent severe AKI. Odds ratio (OR), 95% confidence interval (CI), and P value for each variable in the models are shown in the lower table