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. 2021 May 31;21:287. doi: 10.1186/s12935-021-01991-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — GOLT1B is highly expressed in CRC and predicts poor clinical prognosis. a Comparison of GOLT1B expression level in colon adenocarcinoma and normal tissue in UALCAN database. b Kaplan–Meier survival curves of OS in CRC patients from UALCAN database. c GOLT1B level determined by qRT-PCR (n = 8) and d IHC staining in paired CRC tumor tissues and normal tissues. e. Representative IHC staining of GOLT1B in a tissue microarray of human CRC tissues. f, g Kaplan–Meier survival curves of OS and PFS in 224 CRC patients by GOLT1B expression (P = 0.00003 and P = 0.00011, respectively). Low GOLT1B is defined as IHC score < 5 and High GOLT1B is defined as IHC score ≥ 5