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. 2021 May 31;21:287. doi: 10.1186/s12935-021-01991-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — GOLT1B induces EMT via regulating Wnt/β-catenin pathway. a Heatmap shows the significantly altered 531 genes (P < 0.05, fold change ≥ 1.5) after knocking down of GOLT1B in HCT116 cells (supplementing the detailed gene in Table S2). b, c KEGG and GO analyses of differential expression genes on Dr. Tom platform (BGI-tech, China). d, e GSEA enrichment analysis of differentially expressed genes. f EMT-related gene expression was determined by western blot after downregulation of GOLT1B. g The dual luciferase report experiment showed that overexpression of GOLT1B in HCT116 can activate the Wnt signaling pathway. h Activation of Wnt signaling pathway were analyzed by Western blot analysis