Table 3.

Univariate and multivariate analysis of different parameters for progression-free survival in CRC patients

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male vs female)	1.075 (0.569–1.519)	0.772
Age (> 67 vs ≤ 67)	1.452 (0.889–2.372)	0.137
pT status (T3-T4 vs T1-T2)	3.708 (1.770–7.769)	< 0.001***	1.736 (0.767–3.928)	0.186
pN status (N1-N2 vs N0)	5.456 (3.329–8.941)	< 0.0001****	2.536 (1.420–4.530)	< 0.0017**
pM status (M1 vs M0)	10.387 (6.121–17.627)	< 0.0001****	4.244 (2.385–7.552)	< 0.0001****
Histological grade (G3 vs G1-G2)	0.773 (0.460–1.297)	0.329
Recurrence (YES vs NO)	4.149 (2.043–8.425)	< 0.0001****	2.363 (1.155–4.837)	0.019*
GOLT1B expression (High vs Low)	4.092 (1.953–8.573)	< 0.001***	2.194 (1.002–4.802)	0.049*

Univariate and multivariate Cox proportional hazards regression were used to calculate Hazard ratio (HR), 95% confidence intervals (95% CI) and p values in SPSS 24.0. Low GOLT1B is defined as IHC score < 5 and High GOLT1B is defined as IHC score ≥ 5. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001