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. 2021 May 31;23:63. doi: 10.1186/s12968-021-00754-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Hypertrophic cardiomyopathy (HCM) mice carrying mybpc3 and myh7 gene variants show myocardial hypertrophy. a Representative FLASH cine images (upper row: end-diastole; lower row: end-systole) show mid-ventricular short axis (SAX) views in male B6 (C57BL/6) and D2 (DBA/2J) mouse heart acquired at 9.4 T. Yellow lines outline the thickness of left ventricle (LV). White scale bar = 1 mm. b cine-CMR revealed preserved LV function in D2 HCM mice (male: n = 4, female: n = 4) compared to B6 (male n = 4, female n = 4). Functional assessments (LV thickness, LV ejection fraction (LVEF), data are shown as mean ± SD) were done on a slice-by-slice basis. Endo- and epi-cardiac borders were manually segmented in end-systole and end-diastole using a stack of short axis FLASH cine images. LVEF were calculated for both sexes. Data are shown as the mean ± SD. **p < 0.01, ***p < 0.001 using one-way ANOVA with Tukey’s multiple-comparisons test