Table 4.

Potential uses of live attenuated vaccines LAVs against COVID-19

Use	Population addressed
“Bridge” use (until SARS-CoV-2–specific vaccine becomes available)	General populations
	• Responders (medical, fire, police)
	• At-risk populations (hourly workers, gig workers, undocumented residents)
OPV incremental to SARS-CoV-2 specific vaccine	As an adjuvant concomitant to administration of a COVID-19 vaccine
	• To boost responses in elderly or individuals with comorbidity
Ring use (ring use will generally require single administration of vaccines in well-defined populations as a quick response to appearance of infection)	Quenching postpandemic flare-ups
	• Quenching prepandemic sparks
	• Institutionalized elderly and caretakers
	• Prisoners and guards
	• Other institutionalized groups
Therapeutic use (hypothetical)	• Infected individuals immunized early after detection of infection