Figure 2.

Summary of liquid chromatography/mass spectrometry (LC/MS) and proteomic analyses of isolated cerebrovascular tissue from the inferior frontal gyrus in Alzheimer's disease (AD) and young/aged matched control cases. (A) Shows identified total number of quantified spectra, peptide spectrum matches and non-redundant master protein groups from all plexes used for quantitative proteomic analyses of (B) isolated cerebrovascular tissue from the inferior frontal gyrus [IFG]. (C) Data shows expression levels of distinct genes associated with specific cell types identified from our proteomic analyses of the isolated cerebrovasculature. Data represent abundant ratio expressed in arbitrary units. Venn diagram in (D,E) shows overlapping significantly regulated proteins by t-test in the comparisons between young vs. aged healthy controls cases and Low CAA vs. High CAA vs. Age-matched controls, respectively. (F) Shows heat map of proteins identified from our proteomic analyses between young vs. aged controls, aged control vs. low CAA, aged controls vs. high CAA and low vs. high CAA groups (data represent Log2 fold change).