Table 3.
List of Top 25 proteins significantly regulated in the inferior frontal gyrus cerebrovasculature of low CAA vs. aged-matched control cases.
| Gene name | Uniprot ID | Protein name | Biological function | Log2FC | –Log10 (P value) |
|---|---|---|---|---|---|
| ACTN2 | P35609 | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) | Actin filament uncapping | 0.32 | 2.33 |
| TPM4 | P67936 | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Actin filament organization | −0.31 | 2.04 |
| HPCAL1 | P37235 | Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) | Calcium binding protein | −0.18 | 1.96 |
| TUFM | P49411 | Elongation factor Tu, mitochondrial | Mitochondrial translational elongation | −0.2 | 1.91 |
| RPSA | A0A0C4DG17 | (37 kDa laminin receptor precursor) (37LRP) | Ribosomal small subunit assembly | −0.23 | 1.91 |
| ACTN1 | P12814 | Alpha-actinin-1 cytoskeletal isoform | Actin crosslink formation | −0.2 | 1.88 |
| DECR1 | A0A024R9D7 | 2,4-dienoyl CoA reductase 1, mitochondrial, isoform | Positive regulation of cold-induced thermogenesis | −0.27 | 1.83 |
| MCH-2V | Q53G34 | Mitochondrial carrier homolog 2 variant | Mitochondrial metabolic pathways | −0.42 | 1.73 |
| PRELP | P51888 | Proline-arginine-rich end leucine-rich repeat protein | Cell aging | −0.33 | 1.69 |
| PIPSL | A2A3N6 | Putative PIP5K1A and PSMD4-like protein | Phosphatidylinositol phosphate kinase activity | −0.41 | 1.69 |
| DYNC1I1 | O14576 | Cytoplasmic dynein 1 intermediate chain 1 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | −0.29 | 1.68 |
| HDGFL3 | Q9Y3E1 | Hepatoma-derived growth factor-related protein 3 | Microtubule polymerization | −0.27 | 1.59 |
| FBN1 | P35555 | Fibrillin-1 | Activation of protein kinase A activity | 0.35 | 1.58 |
| PHB | A8K401 | Prohibitin | Activation of phospholipase C activity | −0.19 | 1.57 |
| NDUFB4 | O95168 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Mitochondrial electron transport, NADH to ubiquinone | −0.33 | 1.57 |
| APP | A0A218KGR2 | Alpha-secretase C-terminal fragment (Amyloid-beta A4 protein) | Endocytosis | 0.85 | 1.54 |
| A8K4W2 | ATP synthase F(0) complex subunit B1, mitochondrial | ATP synthesis coupled proton transport | −0.4 | 1.53 | |
| MYL6 | B7Z6Z4 | Myosin light polypeptide 6 | ATPase cellular motor protein. | −0.19 | 1.52 |
| IMMT | Q16891 | MICOS complex subunit MIC60 (Cell proliferation-inducing gene) | Cristae formation | −0.19 | 1.51 |
| TOMM70 | O94826 | Mitochondrial import receptor subunit TOM70 | Macroautophagy | −0.3 | 1.48 |
| HEL-S-99n | V9HW25 | Calreticulin | Binds misfolded proteins preventing export from the ER | −0.5 | 1.47 |
| ABR | A0A1C7CYZ0 | Active breakpoint cluster region-related protein | Intracellular signal transduction | −0.17 | 1.45 |
| ACTN4 | O43707 | Alpha-actinin-4 | Actin filament bundle assembly | −0.17 | 1.44 |
| FARP1 | C9JME2 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Dendrite morphogenesis | −0.24 | 1.44 |
| TPR | P12270 | Nucleoprotein (Translocated promoter region protein) | mRNA transport | −0.64 | 1.41 |
Data are expressed as the negative Log10 of the p-value (significance cut off set at >1.3 or P < 0.05), and the Log 2 fold change between low CAA vs. aged-matched control cases.