Table 4.
List of Top 25 proteins significantly regulated in the inferior frontal gyrus cerebrovasculature of high CAA vs. aged-matched control cases.
| Gene name | Uniprot ID | Protein name | Biological function | Log2FC | –Log10 (P value) |
|---|---|---|---|---|---|
| NDUFA9 | Q16795 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Circadian rhythm | −0.38 | 4.55 |
| DECR1 | A0A024R9D7 | 2,4-dienoyl CoA reductase 1, mitochondrial, isoform | Beta-oxidation enzyme | −0.7 | 4.13 |
| NDUFB3 | O43676 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Mitochondrial electron transport, NADH to ubiquinone | −0.41 | 3.9 |
| NDUFS2 | O75306 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | Mitochondrial ATP synthesis coupled electron transport | −0.39 | 3.75 |
| ATP5F1E | P56381 | ATP synthase subunit epsilon, mitochondrial | ATP biosynthetic process | −0.63 | 3.72 |
| IMMT | Q16891 | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) | Roles in the maintenance of crista junctions | −0.3 | 3.64 |
| NDUFA5 | A0A024R745 | (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5) | Respiratory electron transport chain | −0.68 | 3.63 |
| Q59EI9 | ADP,ATP carrier protein, liver isoform T2 variant | ATP transmembrane transporter activity | −0.36 | 3.51 | |
| NEFM | A5YM63 | 160 kDa neurofilament protein (Neurofilament 3) | Neurofilament bundle assembly | 0.51 | 3.34 |
| DYNLL2 | Q96FJ2 | Dynein light chain 2, cytoplasmic | Antigen processing and presentation of exogenous peptide antigen via MHC class II | −0.42 | 3.3 |
| CPNE5 | Q9HCH3 | Copine-5 (Copine V) | Cellular response to calcium ion | −0.91 | 3.22 |
| ACTN1 | P12814 | Alpha-actinin-1 cytoskeletal isoform | Anchors actin to a variety of intracellular structures | −0.37 | 3.2 |
| UQCRC1 | P31930 | Cytochrome b-c1 complex subunit 1, mitochondrial | Aerobic respiration | −0.32 | 3.2 |
| STX1A | Q75ME0 | STX1A protein Syntaxin 1A (Brain) | Calcium-ion regulated exocytosis | −0.5 | 3.08 |
| AP2A1 | O95782 | AP-2 complex subunit alpha−1 (100 kDa coated vesicle protein A) | Antigen processing and presentation of exogenous peptide antigen via MHC class II | −0.19 | 3.06 |
| ATP5F1C | P36542 | ATP synthase subunit gamma, mitochondrial | ATP biosynthetic process | −0.42 | 3.01 |
| PTPNS1 | D3DVW9 | Protein tyrosine phosphatase, non-receptor type substrate 1 | Negative regulator of the insulin signaling pathway | −0.6 | 2.98 |
| COX6C | P09669 | Cytochrome c oxidase subunit 6C | Generation of precursor metabolites and energy | −0.55 | 2.92 |
| COX5B | P10606 | Cytochrome c oxidase subunit 5B, mitochondrial | Mitochondrial ATP synthesis coupled proton transport | −0.28 | 2.88 |
| PHB | A8K401 | Prohibitin | Chaperone for respiration chain proteins and trancriptional regulation | −0.23 | 2.87 |
| SLC4A4 | A5JJ20 | Anion exchange protein | Transport of anions across cellular barriers | −0.5 | 2.86 |
| PRP1 | B4DJ38 | Pentatricopeptide repeat protein 1 | Negative regulation of leucine tRNA, mitochondria-encoded proteins and COX activity | −0.51 | 2.86 |
| NDUFA8 | P51970 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Mitochondrial electron transport, NADH to ubiquinone | −0.63 | 2.86 |
| PKM2 | A0A024R5Z9 | Pyruvate kinase | Glucose metabolic process | −0.32 | 2.85 |
| ATP5MG | O75964 | ATP synthase subunit g, mitochondrial (ATPase subunit g) | Catalyzes ATP synthesis during oxidative phosphorylation | −0.5 | 2.85 |
Data are expressed as the negative Log10 of the p-value (significance cut off set at >1.3 or P < 0.05), and the Log 2 fold change between high CAA vs. aged-matched control cases.