Table 5.
List of Top 25 proteins significantly regulated in the inferior frontal gyrus cerebrovasculature of low vs. high CAA [AD] cases.
| Gene name | Uniprot ID | Protein name | Biological function | Log2FC | –Log10 (P value) |
|---|---|---|---|---|---|
| LDHB | Q5U077 | L-lactate dehydrogenase | Carbohydrate metabolic process | −0.41 | 2.84 |
| PKM2 | A0A024R5Z9 | Pyruvate kinase | Glycolysis | −0.39 | 2.66 |
| CRYM | Q14894 | Ketimine reductase mu-crystallin | Lysine catabolic process | −0.37 | 2.53 |
| VLC-ACDm | B4DEA8 | Very-long-chain specific acyl-CoAdehydrogenase, mitochondrial | Fatty acid and amino acid catabolism | −0.34 | 2.45 |
| OGDHL | Q9ULD0 | 2-oxoglutarate dehydrogenase-like, mitochondrial | Degrades glucose and glutamate | −0.4 | 2.34 |
| ALDH5A1 | V9HWE0 | Succinate-semialdehyde dehydrogenase | Negative regulation of coagulation | 0.27 | 2.31 |
| ZNF512 | Q96ME7 | Zinc finger protein 512 | DNA and metal ion binding | −0.29 | 2.22 |
| MYO5A | F8W6H6 | Unconventional myosin-Va | Transport of vesicles to the plasma membrane | −0.4 | 2.22 |
| HEL-S-34 | D9IAI1 | Phosphatidylethanolamine binding protein 1 | Serine protease inhibitor which inhibits thrombin | −0.42 | 2.19 |
| ACTN2 | P35609 | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) | Anchor actin to a variety of intracellular structures | −0.33 | 2.02 |
| GAPDH | P04406 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | Canonical glycolysis | −0.37 | 2 |
| ESYT2 | A0A087WXU3 | Extended synaptotagmin-2 | Lipid transport | 0.57 | 1.97 |
| LRRC47 | Q8N1G4 | Leucine-rich repeat-containing protein 47 | RNA binding | −0.32 | 1.95 |
| DECR1 | A0A024R9D7 | 2,4-dienoyl CoA reductase 1, mitochondrial, isoform | Beta-oxidation enzyme | −0.43 | 1.95 |
| DPYSL2 | A0A1C7CYX9 | Dihydropyrimidinase-related protein 2 | Cytoskeleton organization | −0.3 | 1.92 |
| GTPBP4 | D2CFK9 | Nucleolar GTP-binding protein 1 | Maturation of LSU-rRNA from tricistronic rRNA transcript | 0.36 | 1.9 |
| BM88 | B2R7I3 | BM88 antigen (BM88), mRNA | Neuron differentiation | −0.3 | 1.89 |
| AP2A2 | O94973 | Adaptor protein complex AP-2 subunit alpha-2 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | −0.29 | 1.88 |
| CS | O75390 | Citrate synthase, mitochondrial | Carbohydrate metabolic process | −0.34 | 1.87 |
| ALDOA | J3KPS3 | Fructose-bisphosphate aldolase | Glycolytic process [GO:0006096] | −0.28 | 1.87 |
| MLF2 | Q15773 | Myeloid leukemia factor 2 | Regulation of transcription, DNA-templated | −0.34 | 1.87 |
| PROSC | D3DSW3 | Pyridoxal phosphate homeostasis protein | Intracellular homeostatic regulation of vitamin B6 | 0.32 | 1.85 |
| MYO1C | O00159 | Unconventional myosin-Ic (Myosin I beta) | Actin filament organization | 0.3 | 1.82 |
| CKMT1A/1B | P12532 | Creatine kinase U-type, mitochondrial | Creatine metabolic process | −0.38 | 1.82 |
| NDUFA9 | Q16795 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Accessory subunit of the mitochondrial membrane respiratory chain | −0.24 | 1.82 |
Data are expressed as the negative Log10 of the p-value (significance cut off set at >1.3 or P < 0.05), and the Log 2 fold change between low vs. high CAA [AD] cases.