Groups | Gender (Male) | Age (yrs) | ApoE4 allele carrier | Last MMSE score | NIA-R (High) | Neuritic plaque (C3) | NFT stage (B3) | TMT 10 PLEX LABELS |
Young controls (N = 9) | 56% (5/9) | 47 ± 3.3 | 67% (6/9) | N/A | N/A | N/A | N/A | −126, −127N, −128C |
Aged controls (N = 15) | 60% (9/15) | 87.4 ± 1.5 | 20% (3/15) | 28.1 ± 0.5 | 0% (0/15) | 0% (0/15) | 0% (0/15) | −126, −127N, −127C*, −128N |
Low CAA Score (≤4) [AD] (N = 10) | 30% (3/10) | 85.5 ± 2.9 | 40% (4/10) | 16.7 ± 2.4 | 50% (5/10) | 60% (6/10) | 50% (5/10) | −129C,−130N, −130C, −131 |
High CAA Score (≥8) [AD] (N = 10) | 40% (4/10) | 81 ± 4.4 | 60% (6/10) | 14 ± 3.3 | 90% (9/10) | 100% (10/10) | 90% (9/10) | −129N, −129C,−130N, −130C, −131 |
Cx, Cortex; ADNC, Alzheimer's disease neuropathological change; NIA-R, National institute of Aging Regan Diagnosis of AD.