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. 2021 May 17;9:642307. doi: 10.3389/fcell.2021.642307

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Copyright © 2021 Feng, Barb, Allen, Regan and Saligan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Androgen deprivation therapy broadly affected metabolites related to steroid hormone biosynthesis. (A) Androsterone sulfate was significantly decreased in patients with ADT. Sulfated (B–H) and glucuronidated androgen metabolites (I–L) were significantly decreased in the +ADT group. *p < 0.05 and false-discovery rate ≤ 10%.