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. 2021 May 17;9:642307. doi: 10.3389/fcell.2021.642307

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Copyright © 2021 Feng, Barb, Allen, Regan and Saligan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Steroid hormone biosynthesis was associated with fatigue severity. (A) Box plot showing the PROMIS-fatigue T-scores of the −ADT PROMIS-Fatigue T-scores of the −ADT group (44.34 ± 7.81) and the +ADT group (47.92 ± 7.28). *Indicates statistical significance (p = 0.0064). Scores above the dotted lines are considered fatigued (24% of −ADT, 40% of +ADT). (B) Correlations of PROMIS-Fatigue T-score and metabolites that was significantly different between the two groups. X axis indicates the correlation coefficient. Colors of the bars indicate FDR-adjusted p-values. (C) Metabolite set enrichment analysis of metabolites that significantly correlated with PROMIS-Fatigue T-scores. Steroid hormone biosynthesis (KEGG ID: M00107), including androgen and estrogen metabolism (SMPDB ID: SMP0000068) as well as androstenedione metabolism (SMPDB ID: SMP0030406), were significantly overrepresented.