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. 2021 May 17;9:642307. doi: 10.3389/fcell.2021.642307

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Copyright © 2021 Feng, Barb, Allen, Regan and Saligan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced steroid hormone biosynthesis metabolites were associated with increased severity of cancer-related fatigue. PROMIS-Fatigue T-scores significantly correlated with major androgen metabolites including (A) androsterone sulfate (r = –0.26, p = 0.0009), (B) epiandrosterone sulfate (r = –0.25, p = 0.0016), (C) etiocholanolone glucuronide (r = –0.19, p = 0.018), and (D) dehydroepiandrosterone sulfate (DHEA-S) (r = –0.18, p = 0.023). PROMIS-Fatigue T-scores also correlated with sulfated metabolites of androgen including (E) androstenediol (3beta,17beta) monosulfate (r = –0.26, p = 0.0008), (F) 5alpha-androstan-3beta,17beta-diol disulfate (r = –0.21, p = 0.0083), (G) 5alpha-androstan-3beta,17beta-diol monosulfate (r = –0.20, p = 0.012), (H) 5alpha-androstan-3alpha,17alpha-diol monosulfate (r = –0.22, p = 0.0062), and (I) 5alpha-androstan-3beta,17alpha-diol disulfate (r = –0.17, p = 0.028).