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. 2021 May 17;10:577229. doi: 10.3389/fonc.2020.577229

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Copyright © 2021 Chen, Song, Nie, Lin, Yu, Kong, Qi and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCL1 activates JAK-STAT signaling pathway to promote cell proliferation, migration, invasion and inhibit cell apoptosis of CRC. Cells were divided into oe-NC, oe-CXCL1, and oe-CXCL1+AG490 groups. (A) Western blot showed the protein levels of CXCL1 in SW480 cells and the levels of the key proteins involved in JAK-STAT signaling way (p-Jak1, Jak2, p-STAT3, and STAT3), (B) CCK-8, (C) wound healing assay, (D) Transwell invasion assay (100×), and (E) flow cytometry showed the proliferation, migration, invasion and apoptosis of SW480 cells in each group (*p < 0.05).