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Overview of metabolic changes in some immune cell types upon activation. Macrophages, CD4+ T cells and NK cells are shown. Resting or naïve cells typically display a low metabolic rate (low glycolysis, low OxPhos). M0 macrophages differentiate into M1 and M2 macrophages, naïve CD4+ T cells differentiate into Teffs or Tregs, and resting NK cells become activated. Each cell subtype displays different metabolic requirements and repertoire of cytokines to function.
