Table 4.
Effects of GST genotype on urinary MHBMA and DHBMA concentrations at week two baseline.
| GST genotype | N | Geometric mean (95% CI) | |
|---|---|---|---|
| MHBMA (ng/mg Cr)a | DHBMA (ng/mg Cr)a | ||
| GSTT1 | |||
| Null | 18 | 7.8 (4.9, 12.5) | 891.3 (568.8, 1396.8) |
| Present | 61 | 17.1 (13.3, 22.0) | 645.9 (507.5, 822.1) |
| % Difference | 219.5 (28.3, 375.6) | 72.5 (−56.6, 21.1) | |
| P-valueb | 0.01 | 0.22 | |
| GSTM1 | |||
| Null | 36 | 15.1 (10.7, 21.5) | 803.4 (584.3, 1104.5) |
| Present | 43 | 13.6 (9.9, 18.7) | 615.8 (460.6, 823.3) |
| % Difference | 90.0 (−44.4, 45.5) | 76.7 (−50.5, 18.8) | |
| P-valueb | 0.67 | 0.24 | |
Urinary biomarkers were adjusted for creatinine and batch, and log-transformed.
Two-sided p-values were from linear regression models that test the GST genotype effect on week 2 baseline values, after adjusting for creatinine-adjusted TNE.