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. 2021 May 17;12:651105. doi: 10.3389/fphys.2021.651105

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Copyright © 2021 Guo, Zhang, Wang, Huang, Liu, Chu, Ren, Kong and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trx-1 mRNA levels in the hippocampal tissues of the mice and neurobehavioral analysis of Trx-1 transgenic mice. (A) Real-time quantitative PCR of Trx-1 mRNA levels in mouse hippocampal tissue. (B) Latency to platform, ##p < 0.01: WT-NC vs WT-DM; &&p < 0.01: WT-DM vs TG-DM; *p < 0.05, **p < 0.01: TG-NC vs TG-DM. (C) Platform crossing (probe trial), (D) Time spent in the target quadrant (probe trial). (E) Latency to platform (visual trial). (F) Swimming speed. Tukey’s post hoc test for one-way ANOVA was used to determine Trx-1 mRNA levels. For each group, n = 6. The vertical lines represent the standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.