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. 2021 May 17;12:651105. doi: 10.3389/fphys.2021.651105

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Copyright © 2021 Guo, Zhang, Wang, Huang, Liu, Chu, Ren, Kong and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trx-1 significantly inhibits DM-induced apoptosis and neural degeneration in the hippocampal region. (A) Positive cells with a red fluorescence signal (white arrows) were present in the hippocampal as determined by the TUNEL assay. (B) Quantitative statistical analysis of TUNEL-positive cells. (C) Representative images of FJC-positive staining (white arrows) in the hippocampal regions. (D) Quantitative statistical analysis of FJC-positive cells. Tukey’s post hoc test for one-way ANOVA used for TUNEL test. For each group, n = 6. The vertical lines represent the standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.