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. 2021 May 17;12:651105. doi: 10.3389/fphys.2021.651105

FIGURE 4.

FIGURE 4

Effects of DM and Trx-1 on the protein immunocontent of GRP78 and PDI and changes in the activation of PERK, CHOP and caspase-3 in the PERK receptor-related signaling pathway in DM mice. (A) Representative protein expression bands of PERK, p-PERK, CHOP and caspase-3. (B) Representative Western blot analysis of p-PERK/PERK. (C) Representative Western blot analysis of caspase-3. (D) Representative Western blot analysis of CHOP. (E) Representative protein expression bands of GRP78 and PDI. (F) Representative Western blot analysis of GRP78. (G) Representative Western blot analysis of PDI. Tukey’s post hoc test for one-way ANOVA was used to analyze the Western blot immunocontent. For each group, n = 6. The vertical lines represent the standard error of the mean. *p < 0.05, **p < 0.01, and ***p < 0.001.