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. 2021 May 27;14:585–593. doi: 10.2147/JAA.S307197

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© 2021 Blight et al.

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Cell adhesion molecule gene expression is elevated in the sinonasal and blood tissues of patients with CRSwNP compared to controls. (A) The expression of ICAM2 (p<0.001), ICAM3 (p<0.02), ITGAE (p<0.0003), ITGAM (p<0.05), and ITGB2 (p<0.02) is significantly increased in the sinonasal tissues of patients with CRSwNP (n=14) compared to controls (n=10). (B) The expression of, ICAM2 (p<0.05), ICAM3 (p<0.02), ITGAE (p<0.02), and ITGB2 (p<0.001) is significantly increased in the blood of patients with CRSwNP (n=17) compared to controls (n=10). Data are represented as individual values ± standard deviation of the mRNA transcript copy number for each group.

Abbreviations: ICAM1, intercellular adhesion molecule 1; ICAM2, intercellular adhesion molecule 2; ICAM3, intercellular adhesion molecule 3; ITGAE, integrin subunit alpha E; ITGAM, integrin subunit alpha M; ITGAX, integrin subunit alpha X; ITGB1, integrin subunit beta 1; ITGB2, integrin subunit beta 2; CRSwNP, chronic rhinosinusitis with nasal polyps.