Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 27;14:585–593. doi: 10.2147/JAA.S307197

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Blight et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

ITGAM, ICAM-3, and ITGB2 are significantly upregulated in the sinonasal tissues of patients with CRSwNP compared to controls. (A) Representative immunohistochemical images of sinonasal tissues demonstrating the increased expression of ICAM-3 (blue, left panels), ITGB2 (brown, left panels), and ITGAM (blue, right panels) in tissues of patients with CRSwNP compared to controls. The sinonasal tissue expression of ITGAX was similar in CRSwNP and controls. Increased co-staining of ICAM-3 and ITGB2 (left panels) was observed in the submucosa of tissues from patients with CRSwNP compared to controls. Staining controls are shown in the lowest two images for ITGAM/ITGAX and ITGB2/ICAM-3, whereby the top panel displays tissue stained with primary antibodies and without secondary antibodies and the bottom panel demonstrates tissue stained without primary antibodies and with secondary antibodies. The number of cells expressing (B) ITGAM (p<0.001), (C) ITGAX (p<0.3), (D) ICAM-3 (p<0.0001), (E) ITGB2 (p<0.04), and (F) ICAM-3 and ITGB2 (p<0.002) in sinonasal tissues of patients with CRSwNP (n=20) is increased compared to controls (n=8–10). (G) Pearson correlation analysis demonstrates a significant positive correlation between the counts of ITGAM- and ICAM-3/ITGB2-expressing cells in CRSwNP (R=0.55, p<0.02). Data are reported as individual values with upper and lower quartiles ± standard deviation of the mean cell count of respective CAM-positive cells for each group.

Abbreviations: ICAM-3, intercellular adhesion molecule 3; ITGAM, integrin subunit alpha M; ITGAX, integrin subunit alpha X; ITGB2, integrin subunit beta 2; NS, not significant; CRSwNP, chronic rhinosinusitis with nasal polyps.