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. 2021 May 27;14:585–593. doi: 10.2147/JAA.S307197

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© 2021 Blight et al.

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Schematic of the potential mechanisms through which Mac-1 and ICAM-3 mediate inflammatory processes in CRSwNP.

Abbreviations: ICAM-3, intercellular adhesion molecule 3; ITGAM, integrin subunit alpha M; ITGB2, integrin subunit beta 2; CRSwNP, chronic rhinosinusitis with nasal polyps; Mac-1, macrophage-1 antigen, a dimeric integrin complex comprised of alpha M and beta 2 subunits.