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. 2021 May 27;10:155–169. doi: 10.2147/ITT.S306150

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© 2021 Greiner et al.

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Triple combination of PDS0101 vaccine, bintrafusp alfa and NHS-muIL12 leads to significant control of TC-1 tumor growth. B6 mice received PBS, R-DOTAP, PDS0101 vaccine, bintrafusp alfa, or NHS-muIL12 alone or in different combinations. (A) Tumor weights at study end. (B) Number of mice in each treatment group with tumors <300 mm³ at study end. A meta-analysis of two independent experiments is shown. **p <0.01, ****p < 0.0001. Reproduced from Smalley Rumfield C, Pellom ST, Morillon YM II, Schlom J, Jochems C. Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine. J Immunother Cancer. 2020;8(1):e000612.⁴⁹ © Authors (or their employer(s)) 2020. Creative Commons Attribution Non Commercial (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/). With permission from BMJ Publishing Group Ltd.