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. 2021 May 27;10:155–169. doi: 10.2147/ITT.S306150

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© 2021 Greiner et al.

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Combination immunotherapy: a 9-mer neoepitope vaccine, N-803, anti-PD-L1, and NHS-muIL12. (A) Treatment schedule. (B) Percent CD8+ cells in immunofluorescent tumor sections. (C) Clonality of TCRβ chains detected in tumor infiltrates. (D) Tumor growth curves of mice treated as indicated. *p<0.05; **p <0.01; ***p <0.001; ****p <0.0001 (n=5). Reproduced from Lee KL, Benz SC, Hicks KC, Nguyen A, Gameiro SR, Palena C, Sanborn JZ, Su Z, Ordentlich P, Rohlin L, Lee JH, Rabizadeh S, Soon-Shiong P, Niazi K, Schlom J, Hamilton DH. Efficient tumor clearance and diversified immunity through neoepitope vaccines and combinatorial immunotherapy. Cancer Immunol Res. 2019;7(8):1359–1370.⁴⁸ Copyright © 2019, American Association for Cancer Research. All rights reserved.

Abbreviation: TCR, T-cell receptor.