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. 2021 Jan 16;36(2):187–192. doi: 10.1093/mutage/geab003

Figure 3.

Figure 3.

Age-related accumulation of mtDNAT414G mutation in the iris. Total DNA was harvested from the iris of 13 subjects ranging from 38 to 70 years old and 13 subjects ranging from 70 to 94 years old. mtDNAT414G/total mtDNA ratio was determined using Q-PCR. We found a significant higher mtDNAT414G/total mtDNA ratio in the older group (70–94 years old), when compared to the younger 38- to 70-year-old group, with median values of 0.091% and 0.052%, respectively. A Mann–Whitney test was used (*P value < 0.02).