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Age-related accumulation of mtDNAT414G in the corneal stroma. The mtDNAT414G/total mtDNA was analysed in total DNA harvested from the stroma of 14 subjects ranging from 38 to 70 years old and 23 subjects ranging from 70 to 94 years old. mtDNAT414G/total mtDNA ratio was determined by Q-PCR. We found significantly more mtDNAT414G mutation in the older group (0.017%) than in the younger one (0.007%). A Mann–Whitney test has been used (*P value < 0.01).
