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. 2021 Jan 16;36(2):187–192. doi: 10.1093/mutage/geab003

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Figure 6. — mtDNAT^414G/total mtDNA ratio analysis in the macular and peripheral regions of the neural retina and the RPE. After dissection of the neural retina (RET) and the RPE of 7 patients with a median age of 60, the macular (mac) and peripheral (periph) regions were separated. Total DNA was extracted and mtDNA^T414G/total mtDNA ratio was determined using Q-PCR. Analysis of the mtDNAT^414G/total mtDNA ratio shows no significant difference between the macular and peripheral regions of both neural retina (0.027% and 0.025%, respectively) and RPE (0.011% and 0.014%, respectively).